Prof. dr. Dr SWM Olde Damink(Promoter)
Oncology Surgeon
Currently, ways to improve liver regeneration in the failing liver (hepatocyte Tx, bile-acid nuclear receptor agonism) and in the setting of the interrupted entero-hepatic cycle is a focus area of research. Furthermore, intestinal failure in patients with enterocutaneous fistulae and a central research theme the influence of an interrupted entero-hepatic cycle on gut and liver homeostasis is the main research theme. During the last few years, tumor metabolism in HPB tumors and the response of the host to these carcinomas (cancer cachexia) became a separate line of research. Furthermore, methodological research related to the feasibility of translational research, the use of different clinical endpoints (dichotomous-, composite- and surrogate endpoints), and the integration of high-end metabolic technology (e.g Imaging Mass Spectrometry) in clinical translational research has my strong interest.

- Consultant Surgeon HPB Surgery & Surgical Oncology
- Head of the Division of HPB Surgery, Department of Surgery
- Chair Clinical Care Pathway HPB, Maastricht Comprehensive Cancer Center
- Full Professor of Surgery & Health Scientist (MSc)
- Director of Research Laboratories Department of Surgery
- Head of the Division of Liver & Digestive Health, School of Nutrition and Translational Research in Metabolism (NUTRIM)
- Seconded Professor of Surgery Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery
- Secretary Special Interest Group AIF European Society of Parenteral and Enteral Nutrition (ESPEN)
- Member Board Netherlands Society of Hepatologist (Surgical representative)

Recent five years & important publications:

- Decreased plasma and tissue isoleucine levels after simulated gastrointestinal bleeding by blood gavages in chronic portacaval shunted rats. IF:31.79
- Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. IF:30.08
- Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. IF:33.88
- Protein synthesis is severely diminished following a simulated upper GI bleed in patients with cirrhosis. IF:30.08
- Randomized controlled trial analyzing the effect of 15 or 30 min intermittent Pringle maneuver on hepatocellular damage during liver surgery. IF:30.08
- Acute endotoxemia following transjugular intrahepatic stent-shunt insertion is associated with systemic and cerebral vasodilatation with increased whole body nitric oxide production in critically ill cirrhotic patients. IF:30.08
- Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial. IF:31.37
- Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure IF.30.08
- Distal versus proximal intestinal short-chain fatty acid release in man. IF:31.79
- Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. IF:31.37
- Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial. IF:45.04
- Corrigendum to "Impaired brain glymphatic flow in experimental hepatic encephalopathy" [J Hepatol 69 (2019) 40-49].IF:30.08
- Impaired brain glymphatic flow in experimental hepatic encephalopathy. IF:30.08